Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of <i>Chikungunya</i> nsP2 Cysteine Protease with Antialphavirus Activity-Reference-Cited by-同舟云学术

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity

Published:2024-09-05 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghoshal Anirban¹²,Asressu Kesatebrhan Haile¹²,Hossain Mohammad Anwar¹²^ORCID,Brown Peter J.¹²,Nandakumar Meganathan¹,Vala Anand³^ORCID,Merten Eric M.²⁴,Sears John D.²⁵,Law Isabella⁶,Burdick Jane E.⁶,Morales Noah L.⁶,Perveen Sumera⁷,Pearce Kenneth H.²⁴^ORCID,Popov Konstantin I.²⁴,Moorman Nathaniel J.²⁵,Heise Mark T.²⁵⁶,Willson Timothy M.¹²^ORCID

Affiliation:

1. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej, Bavla Highway, Ahmedabad, Gujarat 382213, India

4. UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

5. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

6. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

7. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

Funder

North Carolina Biotechnology Center

National Institutes of Health

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01346

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