Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design-Reference-Cited by-同舟云学术

Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design

Published:2024-08-12 Issue:16 Volume:67 Page:14210-14233
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Quinn Taylor R.¹^ORCID,Giblin Kathryn A.²,Thomson Clare²^ORCID,Boerth Jeffrey A.¹^ORCID,Bommakanti Gayathri¹,Braybrooke Erin²,Chan Christina²,Chinn Alex J.¹,Code Erin³,Cui Caifeng⁴,Fan Yukai⁴,Grimster Neil P.¹^ORCID,Kohara Keishi²^ORCID,Lamb Michelle L.¹^ORCID,Ma Lina⁴,Mfuh Adelphe M.¹^ORCID,Robb Graeme R.²^ORCID,Robbins Kevin J.¹^ORCID,Schimpl Marianne⁵^ORCID,Tang Haoran⁵,Ware Jamie⁵,Wrigley Gail L.²,Xue Lin⁴,Zhang Yun¹,Zhu Huimin⁴,Hughes Samantha J.²

Affiliation:

1. Early TDE Discovery, Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

2. Early TDE Discovery, Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

3. Discovery Sciences, R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

4. Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China

5. Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, U.K.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01034

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