Chb-M′, an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in <i>p53</i>-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo-Reference-Cited by-同舟云学术

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Chb-M′, an Inhibitor of the RUNX Family Binding to DNA, Induces Apoptosis in p53-Mutated Non-Small Cell Lung Cancer and Inhibits Tumor Growth and Repopulation In Vivo

Published:2024-05-28 Issue:11 Volume:67 Page:9165-9172
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hirose Yuki¹^ORCID,Sato Shinsuke¹,Hashiya Kaori¹,Ooga Mitsuharu¹,Bando Toshikazu¹,Sugiyama Hiroshi¹²^ORCID

Affiliation:

1. Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan

2. Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University, Sakyo, Kyoto 606-8501, Japan

Funder

National Cancer Institute

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00315

Reference48 articles.

1. The RUNX family: developmental regulators in cancer

2. Structure and regulated expression of mammalian RUNX genes

3. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

4. Structural Analyses of DNA Recognition by the AML1/Runx-1 Runt Domain and Its Allosteric Control by CBFβ

5. CBFβ allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium

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