Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression-Reference-Cited by-同舟云学术

Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression

Published:2024-03-13 Issue:6 Volume:67 Page:4916-4935
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Zeren¹,Li Lanjie¹,Zhai Bingxin¹,Hu Mengxuan¹,Huang Lei¹,Huang Shihui¹,Ye Liu¹,Kong Xiangying¹,Xu Jie¹,Bai Jie²,Yan Jingjie²,Zhou Qichen¹,Hu Zheqi¹,Zhang Yuchen¹,Jiang Yuhan²,Zhang Yan²,Qiao Zhou³,Zou Yi¹²^ORCID,Xu Yungen¹²^ORCID,Zhu Qihua¹²^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 211198, China

2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

3. China Pharmaceutical University Center for Analysis and Testing, China Pharmaceutical University, Nanjing 211198, China

Funder

Natural Science Foundation of Jiangsu Province

National Innovation and Entrepreneurship Training Program for Undergraduate

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00077

Reference40 articles.

1. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

2. PARP-1 and its associated nucleases in DNA damage response

3. Replication fork reversal and the maintenance of genome stability

4. The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

5. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Overcoming Chemoresistance in Cancer: The Promise of Crizotinib;Cancers;2024-07-07

2. Recent advances in c-Met-based dual inhibitors in the treatment of cancers;European Journal of Medicinal Chemistry;2024-06