Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity-Reference-Cited by-同舟云学术

Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity

Published:2024-04-15 Issue:8 Volume:67 Page:6769-6792
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xiang Xinrong¹,Dai Zhengyi¹,Luo Baozhu¹,Zhao Ninglin¹,Liu Song¹,Sui Jing¹,Huang Jiasheng¹,Zhou Yuanzheng¹,Gu Jinlong¹,Zhang Jiangnan¹,Yang Tao¹²^ORCID,Bao Rui¹^ORCID,Luo Youfu¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

2. Laboratory of Human Diseases and Immunotherapies, West China Hospital and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00338

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4. Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

5. BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

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