Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules-Reference-Cited by-同舟云学术

Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

Published:2024-06-06 Issue:12 Volume:67 Page:10152-10167
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stockinger Florian¹^ORCID,Poc Pascal²³^ORCID,Möhwald Alexander¹,Karch Sandra¹,Häfner Stephanie⁴⁵^ORCID,Alzheimer Christian¹,Sandoz Guillaume⁴⁵,Huth Tobias¹^ORCID,Broichhagen Johannes²³^ORCID

Affiliation:

1. Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany

2. Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany

3. Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany

4. Université Côte d’Azur, CNRS, INSERM, iBV, Nice 06108, Cedex 2, France

5. Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice 06108, Cedex 2, France

Funder

Agence Nationale de la Recherche

Universit?tsbund Erlangen-N?rnberg

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00339

Reference67 articles.

1. Alzheimer's Disease: The Amyloid Cascade Hypothesis

2. The amyloid hypothesis of Alzheimer's disease at 25 years

3. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

4. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

5. Purification and cloning of amyloid precursor protein β-secretase from human brain

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