Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability-Reference-Cited by-同舟云学术

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability

Published:2024-03-14 Issue:6 Volume:67 Page:5032-5052
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Xiaoyu¹,Zhao Tong¹,Wang Shuo¹,Xu Shujing¹,Liao Hui²,Gao Shenghua¹,Gao Zhen¹,Zhang Jian¹,Qi Danhui¹,Zhang Zhijiao¹,Zheng Fengxin²,Wang Youzhao³,Wang Zhenqian¹,Yang Mingyu¹,Yang Qian¹,Yi Fan³,Pang Jianxin²^ORCID,Liu Xinyong¹^ORCID,Zhan Peng¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, 250012 Shandong, PR China

2. School of Pharmaceutical Sciences, Southern Medical University, 1838 North Guangzhou Ave, Guangzhou 510515, PR China

3. The Key Laboratory of Infection and Immunity of Shandong Province, Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China

Funder

National Natural Science Foundation of China

Shandong Laboratory Program

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00136

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