Discovery and Evaluation of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives as New Candidates for α-Synuclein PET Imaging

Author:

Zeng Qi1,Zhang Xiaojun2,Li Yuying1,Zhang Qilei3,Dai Jiapei4ORCID,Yan Xiao-xin3,Liu Yu5ORCID,Zhang Jinming2,Liu Sen6,Cui Mengchao17ORCID

Affiliation:

1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P.R. China

2. Nuclear Medicine Department, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, P.R. China

3. Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha 410013, P.R. China

4. Wuhan Institute for Neuroscience and Neuroengineering, South-Central Minzu University, Wuhan 430074, P.R. China

5. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P.R. China

6. Beijing Hesu Pharmaceuticals Inc., Beijing 101500, China

7. Center for Advanced Materials Research, Beijing Normal University at Zhuhai, Zhuhai 519087, P.R. China

Funder

National Natural Science Foundation of China

Science Innovation 2030-Brain Science and Brain-Inspired Intelligence Technology Major Projects

Publisher

American Chemical Society (ACS)

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