Discovery of <i>gem</i>-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors-Reference-Cited by-同舟云学术

Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors

Published:2024-08-06 Issue:16 Volume:67 Page:13723-13736
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Grosse Sandrine¹,Cooymans Ludwig¹,Embrechts Werner¹^ORCID,McGowan David²^ORCID,Jacoby Edgar¹,Stoops Bart¹,Gupta Kusum³,Ackermann Mark⁴,Alnajjar Sarhad⁵^ORCID,Guillemont Jerome⁶,Jin Zhinan⁷,Kesteleyn Bart¹^ORCID,Matcha Kiran¹^ORCID,Sriboonyapirat Pun⁴,Truong Anh³,Van Den Berg Joke¹,Yu Xiaodi⁸,Herschke Florence¹,Roymans Dirk⁹,Raboisson Pierre¹⁰,Rigaux Peter¹,Jonckers Tim H. M.¹^ORCID

Affiliation:

1. Janssen Research & Development, Janssen Pharmaceutica NV, 2340 Beerse, Belgium

2. Aligos, Gaston Geenslaan 1, 3001 Leuven, Belgium

3. Neuron23 Inc. 343 Oyster Point Blvd, South San Francisco, California 94080, United States

4. LambCure LLC, Corvallis, Oregon 97232, United States

5. Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, U.K.

6. NovAlix, 27106 Val-de-Reuil, France

7. Janssen Pharmaceutica NV, Brisbane, California 94005, United States

8. Janssen Pharmaceutica NV, Spring House, Pennsylvania 19477 United States

9. DNS Life Sciences Consulting, Brandhoefstraat 63, 2300 Turnhout, Belgium

10. Galapagos, General De Wittelaan L112, A3, 2800 Mechelen, Belgium

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00525

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