Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with <i>In Vitro</i> and <i>In Vivo</i> Activity in Neurodegenerative Diseases-Reference-Cited by-同舟云学术

Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases

Published:2024-09-10 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Toledano-Pinedo Mireia¹^ORCID,Porro-Pérez Alicia¹,Schäker-Hübner Linda²,Romero Fernando¹,Dong Min¹,Samadi Abdelouahid³,Almendros Pedro¹^ORCID,Iriepa Isabel⁴⁵,Bautista-Aguilera Òscar M.⁴,Rodríguez-Fernández M. Mercedes⁶,Solana-Manrique Cristina⁷⁸⁹,Sanchis Inmaculada⁷⁸,Mora-Morell Alba⁷⁸,Rodrìguez Ania Canseco¹⁰,Sànchez-Pérez Ana M¹⁰,Knez Damijan¹¹^ORCID,Gobec Stanislav¹¹^ORCID,Bellver-Sanchis Aina¹²¹³^ORCID,Pérez Belén¹⁴,Dobrydnev Alexey V.¹⁵^ORCID,Artetxe-Zurutuza Aizpea¹⁶,Matheu Ander¹⁶¹⁷¹⁸,Siwek Agata¹⁹,Wolak Małgorzata¹⁹,Satała Grzegorz²⁰^ORCID,Bojarski Andrzej J.²⁰^ORCID,Doroz-Płonka Agata²¹,Handzlik Jadwiga²¹,Godyń Justyna²²^ORCID,Więckowska Anna²²^ORCID,Paricio Nuria⁷⁸^ORCID,Griñán-Ferré Christian¹²¹³²³^ORCID,Hansen Finn K.²^ORCID,Marco-Contelles José¹^ORCID

Affiliation:

1. Institute of General Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain

2. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany

3. Department of Chemistry, College of Science, United Arab Emirates University, Al Ain 15551, UAE

4. Universidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química “Andrés M. del Río” (IQAR), 28805 Alcalá de Henares, Madrid, Spain

5. Grupo DISCOBAC, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 28805 Alcalá de Henares, Madrid, Spain

6. Department of Organic Chemistry, Universidad Autónoma de Madrid, Cantoblanco 28049 Madrid, Spain

7. Departamento de Genética, Facultad CC Biológicas, Universidad de Valencia, 46100 Burjassot, Spain

8. Instituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Universidad de Valencia, 46100 Burjassot, Spain

9. Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Europea de Valencia, 46010 Valencia, Spain

10. Insitute of Advanced Materials, INAM, University of Jaume I, Castellón 12071, Spain

11. University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia

12. Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, Universitat de Barcelona (NeuroUB), Av. Joan XXIII 27−31, 08028 Barcelona, Spain

13. Institut de Neurociències, Universitat de Barcelona (NeuroUB), 08035 Barcelona, Spain

14. Department of Pharmacology, Therapeutic and Toxicology. Universitat Autònoma de Barcelona, E-08193 Barcelona, Spain

15. Chemistry Department, Taras Shevchenko National University of Kyiv, Lva Tolstoho Street 12, Kyiv 01033, Ukraine

16. Cellular Oncology group, Biodonostia Health Research Institute, 20014 San Sebastian, Spain

17. CIBERfes, Carlos III Institute, 28029 Madrid, Spain

18. IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain

19. Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland

20. Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smętna St., 31-343 Kraków, Poland

21. Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, 9 Medyczna St., 30-688 Krakow, Poland

22. Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland

23. Spanish Biomedical Research Center in Neurodegenerative Diseases (CIBERNED)-Instituto de Salud Carlos III, 28029 Madrid, Spain

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Agencia Estatal de Investigaci?n

Ag?ncia de Gesti? d'Ajuts Universitaris i de Recerca

Universidad Camilo Jos? Cela

United Arab Emirates University

Generalitat de Catalunya

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01367

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5. ALS Genetics: Gains, Losses, and Implications for Future Therapies