Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome-Reference-Cited by-同舟云学术

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Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome

Published:2024-06-10 Issue:12 Volume:67 Page:10168-10189
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Fan¹²,Dai Zhen¹²³,Xue Ming-yue¹²,Chen Xiao-yi¹²,Liu Juan¹²,Wang Li¹²,Xu Li-li¹²^ORCID,Di Bin¹²^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China

3. Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China

Funder

Natural Science Foundation of Jiangsu Province

Natural Science Foundation of Sichuan Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00343

Reference54 articles.

1. Activation and regulation of the inflammasomes

2. Caspase-1-induced pyroptotic cell death

3. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

4. Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

5. Cryopyrin activates the inflammasome in response to toxins and ATP

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