Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A<sub>2A</sub> Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors-Reference-Cited by-同舟云学术

Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A_2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors

Published:2024-06-07 Issue:12 Volume:67 Page:10490-10507
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Gibae¹^ORCID,Jarhad Dnyandev B.¹,Lee Grim¹,Kim Gyudong¹²,Hou Xiyan¹³,Yu Jinha¹⁴,Lee Chang Soo¹,Warnick Eugene⁵,Gao Zhan-Guo⁵,Ahn Sang Yeop⁶,Kwak Dongik⁶,Park Kichul⁷,Lee Summer Dabin⁷,Park Tae-uk⁸,Jung So-young⁸,Lee Jong Hyun⁹,Choi Jong-Ryoul⁹,Kim Myeongjoong⁹,Kim Donghyun⁹,Kim Bongtae⁹,Jacobson Kenneth A.⁵^ORCID,Jeong Lak Shin¹⁶^ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

2. College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Republic of Korea

3. College of Life Science, Dalian Minzu University, Dalian 116600, People’s Republic of China

4. College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea

5. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States

6. Future Medicine Co., Ltd., 54 Changup-ro, Sujeong-gu, Seongnam, Gyeonggi-do 13449, Republic of Korea

7. LNPsolution, R&D Laboratory, 32 Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi-do 10326, Republic of Korea

8. Preclincial Research Center (PRC), Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea

9. HK inno.N Corp., Seoul 04551, Republic of Korea

Funder

Korea Health Industry Development Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01003

Reference32 articles.

1. Next generation of immune checkpoint inhibitors and beyond

2. A decade of immune-checkpoint inhibitors in cancer therapy

3. Distant metastasis-free survival with adjuvant pembrolizumab for resected stage IIB or IIC melanoma

5. Melanoma