Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation-Reference-Cited by-同舟云学术

Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation

Published:2024-06-22 Issue:13 Volume:67 Page:11103-11124
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bruno Paolo¹^ORCID,Micoli Alessandra²,Corsi Mauro³,Pala Daniele¹,Guariento Sara¹,Fiorelli Claudio¹,Ronchi Paolo¹^ORCID,Fioni Alessandro⁴,Gallo Paola Maria⁴,Marenghi Giulia⁴,Bertolini Serena⁵,Capacchi Silvia¹,Mileo Valentina⁶,Biagetti Matteo⁷,Capelli Anna Maria⁸

Affiliation:

1. Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

2. Drug Discovery Chemistry Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy

3. In Vitro Biology Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy

4. Pharmacokinetics Biochemistry Metabolism Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

5. Pharmacology Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

6. Analytics & Early Formulations Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

7. Pipeline Innovation Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

8. AIR Franchise, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy

Funder

Ministero dello Sviluppo Economico Fondo Crescita Sostenibile Accordi per l?Innovazione

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00610

Reference40 articles.

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