Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads-Reference-Cited by-同舟云学术

Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads

Published:2024-08-22 Issue:17 Volume:67 Page:15756-15779
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patel Akash M.¹^ORCID,Willingham Aarron²,Cheng Alan C.³^ORCID,Tomazela Daniela²,Bowman Eddie⁴,Kofman Esther²,Zhang Fan²,Bao Jianming⁵,Sanzone Jillian R.⁵,Choy Jonathan W.⁴,Flygare John A.¹,Han Jin-Hwan⁴,Pradhan Komal⁴,Kieffer Madeleine¹,Chernyak Natalia¹^ORCID,Akbari Peyman⁴,Liu Ping⁵,Mehmood Rimsha³^ORCID,Naravula Saraswathi²,Hollingsworth Scott A.³^ORCID,Bhagwat Bhagyashree²,Lang Simon B.¹^ORCID,Seganish W. Michael¹^ORCID

Affiliation:

1. Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States

2. Discovery Biologics, Merck & Co. Inc., South San Francisco, California 94080, United States

3. Modeling and Informatics, Merck & Co. Inc., South San Francisco, California 94080, United States

4. Discovery Oncology, Merck & Co. Inc., South San Francisco, California 94080, United States

5. External Discovery Chemistry, Merck & Co. Inc., South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01384

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