X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model-Reference-Cited by-同舟云学术

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X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model

Published:2024-05-31 Issue:11 Volume:67 Page:8730-8756
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mou Jun¹,Ning Xiang-Li¹,Wang Xin-Yue¹,Hou Shu-Yan¹,Meng Fan-Bo¹,Zhou Cong¹,Wu Jing-Wei¹,Li Chunyan¹,Jia Tao¹,Wu Xiaoai²^ORCID,Wu Yong¹^ORCID,Chen Yongping³,Li Guo-Bo¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

2. Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

3. Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China

Funder

Sichuan University

National Key Research and Development Program of China

Science and Technology Department of Sichuan Province

National Natural Science Foundation of China

State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00049

Reference65 articles.

1. Protein post-translational modifications in bacteria

2. How pervasive are post-translational and -transcriptional modifications?

3. Control of protein stability by post-translational modifications

4. Pyroglutamic acid

5. Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon

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