Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations
Author:
Affiliation:
1. AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom
2. Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00227
Reference33 articles.
1. Epidermal growth factor receptor mutations in lung cancer
2. Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR
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4. Osimertinib in UntreatedEGFR-Mutated Advanced Non–Small-Cell Lung Cancer
5. Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
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