<i>In Silico</i> Assisted Identification, Synthesis, and <i>In Vitro</i> Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel-Reference-Cited by-同舟云学术

In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel

Published:2024-05-23 Issue:11 Volume:67 Page:9124-9149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Iraci Nunzio¹^ORCID,Carotenuto Lidia²,Ciaglia Tania³,Belperio Giorgio⁴,Di Matteo Francesca³,Mosca Ilaria⁵,Carleo Giusy²^ORCID,Giovanna Basilicata Manuela⁶,Ambrosino Paolo⁴,Turcio Rita³,Puzo Deborah⁵,Pepe Giacomo³^ORCID,Gomez-Monterrey Isabel⁷^ORCID,Soldovieri Maria Virginia⁵,Di Sarno Veronica³,Campiglia Pietro³^ORCID,Miceli Francesco²,Bertamino Alessia³^ORCID,Ostacolo Carmine³^ORCID,Taglialatela Maurizio²^ORCID

Affiliation:

1. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, Italy

2. Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy

3. Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy

4. Department of Science and Technology, University of Sannio, Via F. De Sanctis, 82100 Benevento, Italy

5. Department of Medicine and Health Science Vincenzo Tiberio, University of Molise, Via C. Gazzani, 86100 Campobasso, Italy

6. Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, P.zza L. Miraglia 2, 80138 Naples, Italy

7. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy

Funder

European Commission

Universit? degli Studi di Salerno

Ministero della Salute

Ministero dell'Universit? e della Ricerca

Regione Campania

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00268

Reference102 articles.

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5. Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells

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