Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition-Reference-Cited by-同舟云学术

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Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition

Published:2024-07-24 Issue:15 Volume:67 Page:12521-12533
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ji Jian’ai¹²,Jin Yuhui¹³,Ma Sinan¹,Zhu Yuxuan¹,Bi Xinyu¹,You Qidong¹³^ORCID,Jiang Zhengyu¹³^ORCID

Affiliation:

1. Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

2. School of Pharmacy, Jiangsu Health Vocational College, Nanjing 210009, Jiangsu, China

3. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Funder

China Postdoctoral Science Foundation

Natural Science Foundation of Jiangsu Province

Science Fund for Distinguished Young Scholars of Jiangsu Province

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00403

Reference56 articles.

1. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

2. The chemical basis of ferroptosis

3. Ferroptosis: mechanisms and links with diseases

4. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

5. Targeting ferroptosis as a vulnerability in cancer

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