Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors-Reference-Cited by-同舟云学术

Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors

Published:2024-04-18 Issue:9 Volume:67 Page:7620-7634
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Ting-Ting¹,Wang Qing¹,Zhou Yuxing¹,Ye Baixin²,Liu Tingting¹,Yan Linyang¹,Fan Jinbao¹,Xu Jiahao¹,Zhou Yingjun¹,Xia Zanxian³^ORCID,Deng Xu¹^ORCID

Affiliation:

1. Xiangya School of Pharmaceutical Sciences, Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, Hunan 410013, China

2. Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 311106, China

3. School of Life Sciences, Central South University, Changsha, Hunan 410013, China

Funder

Department of Science and Technology of Hunan Province

National Key Research and Development Program of China

Science Fund for Distinguished Young Scholars of Hunan Province

National Natural Science Foundation of China

Key Project of Research and Development Plan of Hunan Province

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00454

Reference53 articles.

1. ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

2. State-of-the-art strategies for targeting the DNA damage response in cancer

3. Common mechanisms of PIKK regulation

5. ATM in DNA repair in cancer

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