Structure-Guided Design and Synthesis of a Pyridazinone Series of <i>Trypanosoma cruzi</i> Proteasome Inhibitors-Reference-Cited by-同舟云学术

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Published:2023-07-28 Issue:15 Volume:66 Page:10413-10431
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomas Michael G.¹^ORCID,McGonagle Kate¹^ORCID,Rowland Paul²,Robinson David A.¹,Dodd Peter G.¹,Camino-Díaz Isabel³,Campbell Lorna¹,Cantizani Juan⁴,Castañeda Pablo³,Conn Daniel²,Craggs Peter D.²,Edwards Darren¹,Ferguson Liam¹,Fosberry Andrew²,Frame Laura¹,Goswami Panchali²,Hu Xiao¹,Korczynska Justyna²,MacLean Lorna¹,Martin Julio⁴^ORCID,Mutter Nicole¹,Osuna-Cabello Maria¹,Paterson Christy¹,Peña Imanol⁴,Pinto Erika G.¹,Pont Caterina¹,Riley Jennifer¹,Shishikura Yoko¹,Simeons Frederick R. C.¹,Stojanovski Laste¹,Thomas John¹,Wrobel Karolina¹,Young Robert J.⁵,Zmuda Filip¹^ORCID,Zuccotto Fabio¹,Read Kevin D.¹^ORCID,Gilbert Ian H.¹^ORCID,Marco Maria⁴^ORCID,Miles Timothy J.⁴^ORCID,Manzano Pilar⁴,De Rycker Manu¹^ORCID

Affiliation:

1. Drug Discovery Unit, University of Dundee, School of Life Sciences, Dow Street, Dundee, U.K., DD1 5EH

2. GlaxoSmithKline, Chemistry, Medicines Research Centre, Gunnels Wood Road, Stevenage, U.K., SG1 2NY

3. GlaxoSmithKline, Discovery DMPK, IVIVT, Severo Ochoa 2, PTM, Tres Cantos, Madrid ES 28760, Spain

4. GlaxoSmithKline, Global Health R&D, Severo Ochoa 2, PTM, Tres Cantos, Madrid ES 28760, Spain

5. Blue Burgundy Ltd, Ampthill, Bedfordshire, U.K., MK45 2AD

Funder

Wellcome

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00582

Reference36 articles.

1. Anti-trypanosomatid drug discovery: progress and challenges

2. WHF IASC Roadmap on Chagas Disease

3. https://www.who.int/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis) (accessed January 24th 2023).

4. An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

5. Chagas disease

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