Novel Inhibitory Site Revealed by <b>XAP044</b> Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain-Reference-Cited by-同舟云学术

Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain

Published:2024-05-01 Issue:14 Volume:67 Page:11662-11687
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cristiano Nunzia¹,Cabayé Alexandre¹²^ORCID,Brabet Isabelle³,Glatthar Ralf⁴,Tora Amelie³,Goudet Cyril³^ORCID,Bertrand Hugues-Olivier²,Goupil-Lamy Anne²,Flor Peter J.⁵,Pin Jean-Philippe³^ORCID,McCort-Tranchepain Isabelle¹^ORCID,Acher Francine C.¹⁶^ORCID

Affiliation:

1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Cité, CNRS UMR 8601, 75006 Paris, France

2. BIOVIA Dassault Systèmes, F-78140 Vélizy-Villacoublay Cedex, France

3. Institute of Functional Genomics, University of Montpellier, CNRS, Inserm, 34094 Montpellier, France

4. Novartis Biomedical Research, CH-4002 Basel, Switzerland

5. Laboratory of Molecular and Cellular Neurobiology, Faculty of Biology and Preclinical Medicine, University of Regensburg, 93053 Regensburg, Germany

6. Saints-Pères Paris Institute for the Neurosciences, Université Paris Cité, CNRS UMR 8003, 75006 Paris, France

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche M?dicale

Association Nationale de la Recherche et de la Technologie

French Ministry of Higher Education and Technology

Dassault Syst?mes

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01924

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