Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
Author:
Affiliation:
1. Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany
2. Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00510
Reference23 articles.
1. Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
2. Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
3. STING Agonists for Immuno-Oncology
4. Activation of STING Based on Its Structural Features
5. STING signaling and host defense against microbial infection
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