Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists-Reference-Cited by-同舟云学术

Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists

Published:2024-03-19 Issue:6 Volume:67 Page:4442-4462
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Granberg Kenneth L.¹^ORCID,Sakamaki Shigeki²,Fuchigami Ryuichi²,Niwa Yasuki²,Fujio Masakazu²,Kato Harutoshi²,Bergström Fredrik³,Larsson Niklas⁴,Persson Mikael⁵,Villar Inmaculada C.⁶,Fujita Takuya²,Sugikawa Emiko²,Althage Magnus⁷,Yano Naoko²,Yokoyama Yoshito²,Kimura Junpei²,Lal Mark⁸,Mochida Hideki²

Affiliation:

1. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 43183, Sweden

2. Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227−0033, Japan

3. Drug Metabolism and Pharmacokinetics (DMPK), Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden

4. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden

5. Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden

6. Regulatory Toxicology & Safety Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

7. Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden

8. Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden

Funder

AstraZeneca M?lndal

Mitsubishi Tanabe Pharma Corporation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02183

Reference51 articles.

1. International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides

2. The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

3. Activation of Orphan Receptors by the Hormone Relaxin

4. Relaxin Family Peptides and Their Receptors

5. Experimental relaxation of the pubic ligament of the guinea pig.

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