Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release-Reference-Cited by-同舟云学术

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Published:2023-08-30 Issue:17 Volume:66 Page:12324-12341
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Morese Pasquale A.¹^ORCID,Anthony Nahoum²,Bodnarchuk Michael³^ORCID,Jennings Claire²,Martin Mathew P.²,Noble Richard A.²,Phillips Nicole²,Thomas Huw D.²,Wang Lan Z.,Lister Andrew³,Noble Martin E. M.²,Ward Richard A.³^ORCID,Wedge Stephen R.²,Stewart Hannah L.¹^ORCID,Waring Michael J.¹^ORCID

Affiliation:

1. Cancer Research Horizons Therapeutic Innovation, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

2. Cancer Research Horizons Therapeutic Innovation, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Paul O’Gorman Building, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.

3. Oncology iMed, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00845

Reference21 articles.

1. Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments

2. Controlled drug delivery vehicles for cancer treatment and their performance

3. Molecular Delivery of Cytotoxic Agents via Integrin Activation

4. Strategies and challenges to improve the performance of tumor-associated active targeting

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs;Chemical Communications;2024

2. The expanding repertoire of covalent warheads for drug discovery;Drug Discovery Today;2023-12