Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2′-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2′-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors

Published:2023-07-26 Issue:15 Volume:66 Page:10579-10603
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Hua¹²,Zhou Shijia¹²,Plewka Jacek³^ORCID,Wu Caiyun¹²,Zhu Mengyu¹²,Yu Qimeng¹²,Musielak Bogdan³^ORCID,Wang Xiao¹²,Awadasseid Annoor¹²,Magiera-Mularz Katarzyna³^ORCID,Wu Yanling⁴,Zhang Wen¹²^ORCID

Affiliation:

1. Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China

2. Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, China

3. Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland

4. Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China

Funder

National Natural Science Foundation of China

Zhejiang Provincial Key Discipline of Chemical Biology

Zhejiang Leading Innovation and Entrepreneurship Team

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00731

Reference51 articles.

1. Immunotherapy revolutionises non-small-cell lung cancer therapy: Results, perspectives and new challenges

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