Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web Tool for Triaging Compounds with Undesired Pharmacokinetics Profiles-Reference-Cited by-同舟云学术

Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web Tool for Triaging Compounds with Undesired Pharmacokinetics Profiles

Published:2024-04-03 Issue:8 Volume:67 Page:6508-6518
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rath Marielle¹^ORCID,Wellnitz James¹^ORCID,Martin Holli-Joi¹^ORCID,Melo-Filho Cleber¹,Hochuli Joshua E.¹,Silva Guilherme Martins¹^ORCID,Beasley Jon-Michael¹,Travis Maxfield¹,Sessions Zoe L.¹,Popov Konstantin I.¹,Zakharov Alexey V.²^ORCID,Cherkasov Artem³^ORCID,Alves Vinicius¹,Muratov Eugene N.¹^ORCID,Tropsha Alexander¹^ORCID

Affiliation:

1. Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

2. National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

3. Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V6H3Z6, Canada

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

National Institute of Allergy and Infectious Diseases

American Foundation for Pharmaceutical Education

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02446

Reference100 articles.

1. Computational methods in drug discovery

2. An analysis of the attrition of drug candidates from four major pharmaceutical companies

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