Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation-Reference-Cited by-同舟云学术

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Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation

Published:2024-01-24 Issue:3 Volume:67 Page:2019-2030
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kailass Karishma¹^ORCID,Casalena Dominick²,Jenane Lina¹,McEdwards Gregor³,Auld Douglas S.²^ORCID,Sadovski Oleg¹,Kaye Esther G.¹^ORCID,Hudson Elyse¹,Nettleton David²,Currie Mark A.³,Beharry Andrew A.¹^ORCID

Affiliation:

1. Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6

2. Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States

3. Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada, L5L 1C6

Funder

Canada Foundation for Innovation

Ontario Research Foundation

Natural Sciences and Engineering Research Council of Canada

Cancer Research Society

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01850

Reference56 articles.

1. Pancreatic cancer in 2021: What you need to know to win

2. Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma

3. CES2 Expression in Pancreatic Adenocarcinoma Is Predictive of Response to Irinotecan and Is Associated With Type 2 Diabetes

4. Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

5. Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases

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