Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation

Author:

Kailass Karishma1ORCID,Casalena Dominick2,Jenane Lina1,McEdwards Gregor3,Auld Douglas S.2ORCID,Sadovski Oleg1,Kaye Esther G.1ORCID,Hudson Elyse1,Nettleton David2,Currie Mark A.3,Beharry Andrew A.1ORCID

Affiliation:

1. Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada L5L 1C6

2. Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States

3. Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada, L5L 1C6

Funder

Canada Foundation for Innovation

Ontario Research Foundation

Natural Sciences and Engineering Research Council of Canada

Cancer Research Society

Publisher

American Chemical Society (ACS)

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