Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein-Reference-Cited by-同舟云学术

Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein

Published:2023-10-05 Issue:20 Volume:66 Page:14208-14220
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jézéquel Gwenaëlle¹,Rampal Céline¹,Guimard Carole¹,Kovacs David¹,Polidori Joël²,Bigay Joëlle²,Bignon Jérôme¹,Askenatzis Laurie¹,Litaudon Marc¹^ORCID,Pham Van-Cuong³,Huong Doan T. M.³,Nguyen Anvi Laetitia⁴,Pruvost Alain⁴,Virolle Thierry⁵,Mesmin Bruno²,Desrat Sandy¹,Antonny Bruno²,Roussi Fanny¹^ORCID

Affiliation:

1. Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198 Gif-sur-Yvette, France

2. Université Côte d’Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, 06560 Valbonne, France

3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, 10000 Hanoi, Vietnam

4. CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris Saclay, SPI, 91191 Gif-sur-Yvette, France

5. Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, U1091, UMR7277, Parc Valrose, 06000 Nice,France

Funder

Agence Nationale de la Recherche

Soci?t? d'Acc?l?ration du Transfert de Technologies

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01298

Reference33 articles.

1. Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

2. Vedelianin, a hexahydroxanthene derivative isolated from Macaranga vedeliana

3. Cytotoxic Geranyl Stilbenes from Macaranga schweinfurthii

4. Schweinfurthin D, A Cytotoxic Stilbene fromMacaranga schweinfurthii

5. Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest,1

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