Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity-Reference-Cited by-同舟云学术

Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity

Published:2023-06-01 Issue:12 Volume:66 Page:7943-7958
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lammi Carmen¹^ORCID,Fassi Enrico M. A.¹^ORCID,Manenti Marco²,Brambilla Marta³,Conti Maria³^ORCID,Li Jianqiang¹^ORCID,Roda Gabriella¹,Camera Marina¹³,Silvani Alessandra²^ORCID,Grazioso Giovanni¹^ORCID

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

2. Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 10, 20133 Milan, Italy

3. Centro Cardiologico Monzino IRCCS, via Parea 4, 20138 Milan, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00279

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4. PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36

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