Structure–Activity Relationship of FL118 Platform Position 7 Versus Position 9-Derived Compounds and Their Mechanism of Action and Antitumor Activity-Reference-Cited by-同舟云学术

Structure–Activity Relationship of FL118 Platform Position 7 Versus Position 9-Derived Compounds and Their Mechanism of Action and Antitumor Activity

Published:2023-12-15 Issue:24 Volume:66 Page:16888-16916
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Wenchao¹^ORCID,Ling Xiang¹²,Wang Ruojiong¹,Xiong Haonan¹,Hu Liuzhi¹,Yang Zhikun¹,Wang Hong¹^ORCID,Zhang Yali³,Wu Wenjie⁴²,Singh Prashant K.⁵,Wang Jianmin³,Li Fengzhi⁴⁶,Li QingYong¹^ORCID

Affiliation:

1. College of Pharmaceutical Sciences & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, China

2. Canget BioTekpharma, LLC, Buffalo, New York 14203, United States

3. Department of Bioinformatics & Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States

4. Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States

5. Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States

6. Developmental Therapeutics (DT) Program, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States

Funder

National Cancer Institute

National Key Research and Development Program of China

China Postdoctoral Science Foundation

Key Research and Development Program of Zhejiang Province

Pancreatic Cancer Action Network

Natural Science Foundation of Zhejiang Province

Qianjiang Talents Fund of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01589

Reference66 articles.

1. Discovery of Survivin Inhibitors and Beyond

2. A Novel Small Molecule FL118 That Selectively Inhibits Survivin, Mcl-1, XIAP and cIAP2 in a p53-Independent Manner, Shows Superior Antitumor Activity

3. A novel Camptothecin analogue inhibits colon cancer development and downregulates the expression of miR-155 in vivo and in vitro