Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis-Reference-Cited by-同舟云学术

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis

Published:2024-03-19 Issue:6 Volume:67 Page:4603-4623
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Yongqiang¹,Hu Tianxing²,Zhang Mengdi³,Song Jiaxing²,Qin Zhen²,Liu Mai²,Ji Jinliang¹,Li Zhiyu²^ORCID,Qiu Zhixia¹^ORCID,Bian Jinlei²^ORCID

Affiliation:

1. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China

2. Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China

3. School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China

Funder

China Association for Science and Technology

State Key Laboratory of Natural Medicines

Qinglan Project of Jiangsu Province of China

China Pharmaceutical University

National Natural Science Foundation of China

Outstanding Youth Foundation of Jiangsu Province

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02092

Reference51 articles.

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4. Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

5. Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review