Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway-Reference-Cited by-同舟云学术

Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway

Published:2023-08-29 Issue:17 Volume:66 Page:12304-12323
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liao Jing¹²³,Yang Jun¹,Li Xiaobo¹,Hu Chenghong¹,Zhu Weiwei¹,Zhou Ying¹,Zou Yu¹,Guo Mi¹,Chen Zhichao¹,Li Xiang¹,Dai Jintian³,Xu Yuye³,Zheng Zhiwei¹⁴,Chen Pan¹⁴,Cho Won-Jea⁴,Liang Guang¹²³^ORCID,Tang Qidong¹³

Affiliation:

1. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

2. School of Pharmacy, Hangzhou Medical College, Hangzhou 311399, China

3. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China

4. College of Pharmacy, Chonnam National University, Gwangju 61186, Korea

Funder

Wenzhou Medical University

University of Chinese Academy of Sciences

Thailand Research Fund

National Natural Science Foundation of China

Zhejiang Provincial Key Scientific Project

Publisher