A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19-Reference-Cited by-同舟云学术

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Published:2024-04-30 Issue:16 Volume:67 Page:13550-13571
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Allerton Charlotte M. N.¹,Arcari Joel T.²,Aschenbrenner Lisa M.²,Avery Melissa²,Bechle Bruce M.²,Behzadi Mohammad Amin³,Boras Britton⁴^ORCID,Buzon Leanne M.²,Cardin Rhonda D.³,Catlin Natasha R.²,Carlo Anthony A.²,Coffman Karen J.²,Dantonio Alyssa²,Di Li²^ORCID,Eng Heather²,Farley Kathleen A.²^ORCID,Ferre Rose Ann⁴,Gernhardt Steven S.²,Gibson Scott A.⁵,Greasley Samantha E.⁴,Greenfield Siennah R.¹,Hurst Brett L.⁵,Kalgutkar Amit S.¹^ORCID,Kimoto Emi²^ORCID,Lanyon Lorraine F.²,Lovett Gabrielle H.¹,Lian Yajing²,Liu Wei⁴,Martínez Alsina Luis A.²,Noell Stephen²,Obach R. Scott²,Owen Dafydd R.¹^ORCID,Patel Nandini C.¹^ORCID,Rai Devendra K.²,Reese Matthew R.²,Rothan Hussin A.³,Sakata Sylvie⁴,Sammons Matthew F.¹^ORCID,Sathish Jean G.³,Sharma Raman²,Steppan Claire M.²,Tuttle Jamison B.¹,Verhoest Patrick R.¹,Wei Liuqing²,Yang Qingyi¹^ORCID,Yurgelonis Irina³,Zhu Yuao³

Affiliation:

1. Pfizer Research & Development, Cambridge, Massachusetts 02139, United States

2. Pfizer Research & Development, Groton, Connecticut 06340, United States

3. Pfizer Research & Development, Pearl River, New York 10965, United States

4. Pfizer Research & Development, La Jolla, California 92121, United States

5. Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02469

Reference27 articles.

1. From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses