Toward More Selective Antibiotic Inhibitors: A Structural View of the Complexed Binding Pocket of <i>E. coli</i> Peptide Deformylase-Reference-Cited by-同舟云学术

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Toward More Selective Antibiotic Inhibitors: A Structural View of the Complexed Binding Pocket of E. coli Peptide Deformylase

Published:2024-04-04 Issue:8 Volume:67 Page:6384-6396
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kirschner Hendrik¹,Heister Nicole¹,Zouatom Manuela²,Zhou Tianyi²,Hofmann Eckhard³^ORCID,Scherkenbeck Jürgen²^ORCID,Stoll Raphael¹^ORCID

Affiliation:

1. Biochemistry II, Biomolecular NMR Spectroscopy, RUBiospec|NMR, and PhenomeCentre@RUBUAR, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany

2. Faculty of Mathematics and Natural Sciences, Bioorganic Chemistry, University of Wuppertal, Gaußstraße 20, Wuppertal 42119, Germany

3. Protein Crystallography, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, Bochum 44801, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02382

Reference82 articles.

1. On the release of the formyl group from nascent protein

2. A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

3. Enzymatic properties of Escherichia coli peptide deformylase

4. Iron center, substrate recognition and mechanism of peptide deformylase

5. Structure of Peptide Deformylase and Identification of the Substrate Binding Site

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