Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson’s Disease
Author:
Affiliation:
1. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, 70211 Kuopio, Finland
2. Viikki Metabolomics Unit, Department of Biosciences, University of Helsinki, Viikinkaari 5 E, 00014 Helsinki, Finland
Funder
Terveyden Tutkimuksen Toimikunta
Helsinki Institute of Life Science, Helsingin Yliopisto
Business Finland
Sigrid Juselius Foundation
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00235
Reference62 articles.
1. Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography.
2. Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding
3. New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases
4. On the role of prolyl oligopeptidase in health and disease
5. Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Indole-based thiosemicarbazones for neurodegenerative diseases as prolyl oligopeptidase inhibitors;Journal of Molecular Structure;2024-09
2. Structural visualization of inhibitor binding in prolyl oligopeptidase;Biophysics Reviews;2024-08-22
3. Synthesis, biological evaluation, and molecular modelling of substituted thiazolyl thiourea derivatives: A new class of prolyl oligopeptidase inhibitors;International Journal of Biological Macromolecules;2024-08
4. 5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions;Journal of Medicinal Chemistry;2024-03-28
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3