Protective Efficacy of Novel Engineered Human ACE2-Fc Fusion Protein Against Pan-SARS-CoV-2 Infection In Vitro and in Vivo-Reference-Cited by-同舟云学术

Protective Efficacy of Novel Engineered Human ACE2-Fc Fusion Protein Against Pan-SARS-CoV-2 Infection In Vitro and in Vivo

Published:2023-12-15 Issue:24 Volume:66 Page:16646-16657
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Bo¹,Drelich Aleksandra²,Hsu Jason³,Tat Vivian⁴,Peng Bi-Hung⁵,Wei Qisheng¹,Wang Jianming¹,Wang Hong¹,Wages John¹^ORCID,Mendelsohn Andrew R.¹,Larrick James W.¹,Tseng Chien-Te²³⁴⁶

Affiliation:

1. Larix Bioscience LLC, Sunnyvale, California 94089, United States

2. Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555, United States

3. Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States

4. Pathology, University of Texas Medical Branch, Galveston, Texas 77555, United States

5. Neuroscience, Cell Biology & Anatomy, University of Texas Medical Branch, Galveston, Texas 77555, United States

6. Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch, Galveston, Texas 77555, United States

Funder

Centers for Disease Control and Prevention

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01201

Reference68 articles.

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2. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

3. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

4. Omicron: A heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escape approved COVID-19 therapeutic antibodies

5. Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

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