Identification of Cellular Protein Targets of a Half-Sandwich Iridium(III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses-Reference-Cited by-同舟云学术

Identification of Cellular Protein Targets of a Half-Sandwich Iridium(III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses

Published:2024-04-05 Issue:8 Volume:67 Page:6189-6206
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ramos Robin¹^ORCID,Karaiskou Anthi¹,Botuha Candice²,Amhaz Sadek¹,Trichet Michaël³,Dingli Florent⁴,Forté Jérémy²,Lam France³,Canette Alexis³,Chaumeton Chloé³,Salome Murielle⁵,Chenuel Thomas⁶,Bergonzi Céline⁶,Meyer Philippe⁶,Bohic Sylvain⁷^ORCID,Loew Damarys⁴,Salmain Michèle²^ORCID,Sobczak-Thépot Joëlle¹^ORCID

Affiliation:

1. Sorbonne Université, INSERM, Centre de Recherche Saint Antoine, 184 rue du Faubourg Saint Antoine, F-75012 Paris, France

2. Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, 4 place Jussieu, F-75005 Paris, France

3. Sorbonne Université, CNRS, Institut de Biologie Paris-Seine, Service d’imagerie cellulaire, F-75005 Paris, France

4. Institut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, F-75248 Paris, France

5. ESRF, The European Synchrotron Research Facility, F-38043 Grenoble cedex 9, France

6. Sorbonne Université, PSL, CNRS, UMR8226, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, F-75005 Paris, France

7. Université Grenoble Alpes, INSERM, UA7 STROBE, Synchrotron Radiation for Biomedicine, F-38400 Saint Martin d’Hères, France

Funder

Agence Nationale de la Recherche

Institut National de la Sant? et de la Recherche M?dicale

Fondation ARC pour la Recherche sur le Cancer

Institut National Du Cancer

Alliance Nationale pour les Sciences de la Vie et de la Sant?

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02000

Reference67 articles.

1. Advances in novel iridium (III) based complexes for anticancer applications: A review

2. Recent advances of iridium(III) metallophosphors for health-related applications

3. Targeted photoredox catalysis in cancer cells

4. Cyclometalated iridium(III) complexes for life science

5. Organometallic Iridium Arene Compounds: The Effects of C-Donor Ligands on Anticancer Activity