Discovery of Clinically Used Octenidine as <i>NRAS</i> Repressor That Effectively Inhibits <i>NRAS</i>-Mutant Melanoma-Reference-Cited by-同舟云学术

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Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma

Published:2023-03-24 Issue:7 Volume:66 Page:5171-5184
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Xiu-Cai¹^ORCID,Tang Gui-Xue¹,Dai Jing¹,Dai Le-Tian¹,Wu Tian-Ying¹,Li Wen-Wei¹,Ou Tian-Miao¹^ORCID,Huang Zhi-Shu¹^ORCID,Tan Jia-Heng¹^ORCID,Chen Shuo-Bin¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

Funder

Ministry of Education of the People's Republic of China

Guangdong Provincial Key Laboratory of Construction Foundation

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Outstanding Talents of Guangdong Special Plan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00094

Reference54 articles.

1. Nras in melanoma: Targeting the undruggable target

2. Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

3. Targeting mutant NRAS signaling pathways in melanoma

4. RAS Proteins and Their Regulators in Human Disease

5. NRAS mutant melanoma: biological behavior and future strategies for therapeutic management

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