Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor-Reference-Cited by-同舟云学术

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor

Published:2024-02-28 Issue:5 Volume:67 Page:4063-4082
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kesteleyn Bart¹^ORCID,Bonfanti Jean-François²,Bardiot Dorothée³,De Boeck Benoît¹,Goethals Olivia⁴,Kaptein Suzanne J. F.⁵^ORCID,Stoops Bart¹,Coesemans Erwin¹,Fortin Jérôme²,Muller Philippe²,Doublet Frédéric²,Carlens Gunter³,Koukni Mohamed³,Smets Wim³,Raboisson Pierre¹,Chaltin Patrick³⁶,Simmen Kenny¹,Loock Marnix Van⁴,Neyts Johan⁵⁷,Marchand Arnaud³^ORCID,Jonckers Tim H. M.¹^ORCID

Affiliation:

1. Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium

2. Janssen Infectious Diseases Discovery, Janssen-Cilag, Chaussée du Vexin, Val de Reuil 27106, France

3. CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium

4. Janssen Global Public Health R&D, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium

5. KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, Leuven 3000, Belgium

6. Centre for Drug Design and Discovery (CD3), KU Leuven, Bioincubator 2, Gaston Geenslaan 2, Leuven 3000, Belgium

7. Global Virus Network (GVN), Baltimore, Maryland 21201, United States

Funder

Agentschap Innoveren en Ondernemen

Wellcome Trust

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02336

Reference35 articles.

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2. World Health Organisation. Global Strategy for Dengue Prevention and Control, 2012–2020 2012. http://apps.who.int/iris/bitstream/10665/75303/1/9789241504034_eng.pdf?ua=1 (accessed 2020 27 November).

3. Epidemiology of dengue: past, present and future prospects

4. World Health Organization. Dengue Fact Sheets. Dengue and Severe Dengue. 2023. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue (accessed 2021 28 June).

5. The current and future global distribution and population at risk of dengue

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