Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo-Reference-Cited by-同舟云学术

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Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo

Published:2024-01-11 Issue:2 Volume:67 Page:1563-1579
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pang Xudong¹²^ORCID,Cui Dawei²,Lv Binhua²,Wang Cheng-Yun¹^ORCID

Affiliation:

1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

2. Shanghai Zelgen Pharma-Tech Co., Ltd., Building 3, No. 999, Cailun Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China

Funder

Natural Science Foundation of Shanghai Municipality

Shanghai Zelgen Pharma-Tech Co., Ltd

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02135

Reference55 articles.

1. The Son of sevenless Gene Product: a Putative Activator of Ras

2. The Two Hats of SOS

3. The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

4. Understanding SOS (Son of Sevenless)

5. Targeting Son of Sevenless 1: The pacemaker of KRAS

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor;Bioorganic & Medicinal Chemistry Letters;2024-07

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