X-Ray Conformation and Structure–Activity Relationships of MA026, a Reversible Tight Junction Opener

Author:

Mukaiyama Minagi1,Uchiyama Chihiro2,Fukuda Akane2,Nakazawa Yoshiki2,Kuramochi Yuka2,Shibata Yudai2,Konno Sho2,Muguruma Kyohei2,Matsugaki Naohiro34,Asari Tomo2,Ogawa Kazuyoshi5ORCID,Taguchi Akihiro2,Takayama Kentaro2,Taniguchi Atsuhiko2,Nagumo Yoko56,Senda Toshiya734,Hayashi Yoshio2ORCID,Usui Takeo68ORCID

Affiliation:

1. Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan

2. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

3. Structural Biology Research Center, High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Tsukuba, Ibaraki 305-0801, Japan

4. Department of Materials Structure Science, School of High Energy Accelerator Science, The Graduate University of Advanced Studies (Soken-dai), 1-1 Oho, Tsukuba, Tsukuba, Ibaraki 305-0801, Japan

5. Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan

6. Institute of Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan

7. Institute of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan

8. Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan

Funder

Japan Society for Bioscience, Biotechnology, and Agrochemistry

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

KOSÉ Cosmetology Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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