Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy

Author:

Sang Ruoxi12,Fan Renming12,Deng Aohua12,Gou Jiakui3,Lin Ruizhuo12,Zhao Ting3,Hai Yongrui12,Song Junke4,Liu Yang3ORCID,Qi Bing5,Du Guanhua4,Cheng Maosheng3ORCID,Wei Gaofei12ORCID

Affiliation:

1. Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong 518057, China

2. Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China

3. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

4. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

5. Institute of Oncology, The Second Affiliated Hospital, Xi’an Medical University, Xi’an, Shaanxi 710038, China

Funder

China Association for Science and Technology

Science and Technology Foundation of Shenzhen City

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Innovation Capability Support Program of Shaanxi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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