Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors-Reference-Cited by-同舟云学术

Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors

Published:2024-04-17 Issue:9 Volume:67 Page:7048-7067
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Falke Sven¹^ORCID,Lieske Julia¹,Herrmann Alexander²,Loboda Jure³,Karničar Katarina³⁴,Günther Sebastian¹,Reinke Patrick Y. A.¹,Ewert Wiebke¹,Usenik Aleksandra³⁴^ORCID,Lindič Nataša³,Sekirnik Andreja³,Dretnik Klemen³⁵,Tsuge Hideaki⁶,Turk Vito³,Chapman Henry N.¹⁷⁸^ORCID,Hinrichs Winfried⁹^ORCID,Ebert Gregor²¹⁰,Turk Dušan³⁴,Meents Alke¹

Affiliation:

1. Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany

2. Institute of Virology, Helmholtz Munich, Ingolstädter Landstraße 1, 85764 Neuherberg, Munich, Germany

3. Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia

4. Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova 39, 1000 Ljubljana, Slovenia

5. The Jožef Stefan International Postgraduate School, Jamova cesta 39, 1000 Ljubljana, Slovenia

6. Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan

7. Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany

8. Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany

9. Institute of Biochemistry, Universität Greifswald, Felix-Hausdorff-Str. 4, 17489 Greifswald, Germany

10. Institute of Virology, Technical University of Munich, Trogerstraße 30, 81675 Munich, Germany

Funder

Bundesministerium fÃ¼r Bildung und Forschung

Javna Agencija za Raziskovalno Dejavnost RS

European Commission

Helmholtz-Gemeinschaft

Deutsche Forschungsgemeinschaft

Helmholtz Association

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02351

Reference77 articles.

1. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

2. TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

3. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

4. Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

5. Padmanabhan, P.; Dixit, N. M. Modelling How the Altered Usage of Cell Entry Pathways by the SARS-CoV-2 Omicron Variant May Affect the Efficacy and Synergy of TMPRSS2 and Cathepsin B/L Inhibitors Microbiology 2022 10.1101/2022.01.13.476267.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent discovery of natural substances with cathepsin L-inhibitory activity for cancer metastasis suppression;European Journal of Medicinal Chemistry;2024-11