Discovery, Optimization, and Evaluation of Novel Pyridin-2(1<i>H</i>)-one Analogues as Potent TRK Inhibitors for Cancer Treatment-Reference-Cited by-同舟云学术

Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment

Published:2024-01-16 Issue:2 Volume:67 Page:1168-1183
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Zichao¹²³,Peng Xia²,Zhang Renjie⁴³,Ji Yinchun²,You Mengke²³,Wang Danyi²³,Shen Yanyan²,Zheng Mingyue²⁴^ORCID,Li Chunpu²⁴³^ORCID,Ai Jing²³,Liu Hong¹²⁴³^ORCID

Affiliation:

1. School of Life Science and Technology, Shanghai Tech University, Shanghai 200031, China

2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China

Funder

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

Lingang Laboratory

SA-SIBS Scholarship Program

Shanghai Municipal Commission of Health and Family Planning

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01645

Reference23 articles.

1. Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

2. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

3. The nerve growth factor: Thirty-five years later

4. The trk family of tyrosine protein kinase receptors

5. Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics

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