Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator-Reference-Cited by-同舟云学术

Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator

Published:2024-03-26 Issue:7 Volume:67 Page:5259-5271
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomson Christopher G.¹^ORCID,Aicher Thomas D.²^ORCID,Cheng Weiwei³,Du Hongwen³,Dudgeon Crissy⁴,Li An-Hu⁴,Li Baozhong³,Lightcap Eric⁴^ORCID,Luo Diheng⁵,Mulvihill Mark⁴,Pan Pengwei³,Rahemtulla Benjamin F.¹^ORCID,Rigby Alan C.⁴,Sherborne Bradley¹,Sood Sanjeev⁶,Surguladze David⁴,Talbot Eric P. A.¹^ORCID,Tameire Feven⁴,Taylor Simon¹,Wang Yi³,Wojnarowicz Paulina⁴^ORCID,Xiao Fenfen⁵,Ramurthy Savithri⁴

Affiliation:

1. Integrated Drug Discovery Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K.

2. Department of Chemistry, Lycera Corporation, Ann Arbor, Michigan 48103, United States

3. Pharmaron Beijing, Company Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China

4. HiberCell Inc., 619 West 54th Street, New York, New York 10019, United States

5. Pharmaron Xi’an, Company Ltd., No. 1, 12th Fengcheng Road, Xi’an 710018, China

6. Preformulation and Preclinical Services, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, U.K.

Funder

HiberCell Inc.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02384

Reference34 articles.

1. The integrated stress response

2. Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain

3. Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

4. Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

5. Mechanism of PKR Activation by dsRNA

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multifaceted role of GCN2 in tumor adaptation and therapeutic targeting;Translational Oncology;2024-11

2. Druggable genome-wide Mendelian randomization for identifying the role of integrated stress response in therapeutic targets of bipolar disorder;Journal of Affective Disorders;2024-10

3. Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation;2024-06-10