Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51-Reference-Cited by-同舟云学术

Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51

Published:2023-04-14 Issue:8 Volume:66 Page:5965-5980
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Knaup Fabian H.¹,Meyners Christian¹,Sugiarto Wisely Oki¹,Wedel Saskia²,Springer Margherita³,Walz Carlo¹^ORCID,Geiger Thomas M.¹,Schmidt Mathias³,Sisignano Marco²⁴,Hausch Felix¹⁵^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany

2. Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

3. Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804 Munich, Germany

4. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany

5. Centre for Synthetic Biology, Technical University of Darmstadt, 64283 Darmstadt, Germany

Funder

Bundesministerium f?r Bildung und Forschung

LOEWE cluster TRABITA

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00249

Reference51 articles.

1. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

2. C-terminal Sequences outside the Tetratricopeptide Repeat Domain of FKBP51 and FKBP52 Cause Differential Binding to Hsp90

3. FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells

4. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

5. FKBP51 and FKBP52 in signaling and disease

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis;Stem Cell Research & Therapy;2024-07-18

2. 1,4‐Pyrazolyl‐Containing SAFit‐Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug‐Like Profile;ChemMedChem;2024-07-08

3. Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction;European Journal of Medicinal Chemistry;2024-04

4. Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets;ACS Central Science;2024-02-28

5. Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries;Physiological Reviews;2024-01-01