Development of Integrated Bioorthogonal Self-Catalyzed NO Donor/Platinum(IV) Prodrugs for Synergistical Intervention against Triple-Negative Breast Cancer

Author:

Zhang Chen1,Zhu Jie1,Yuan Xun1,Yan Zhengsheng1,Ye Hui1ORCID,Xiong Tao1,Xu Anning1,Li Cunrui1,Ji Duorui1,Yang Shan2,Zhang Juan3ORCID,Zhang Yihua1ORCID,Wu Jianbing1ORCID,Huang Zhangjian14ORCID

Affiliation:

1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, P. R. China

2. Xinjiang Key Laboratory of Neurological Disorder Research, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, P. R. China

3. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P. R. China

4. School of Pharmacy, Key Laboratory of Active Components of Xinjiang Natural Medicine and Drug Release Technology, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, Xinjiang Medical University, Urumqi 830054, P. R. China

Funder

China Pharmaceutical University

Natural Science Foundation of Xinjiang Uygur Autonomous Region

National Natural Science Foundation of China

Science and Technology Supporting Xinjiang Project

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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