Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer-Reference-Cited by-同舟云学术

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Published:2023-11-29 Issue:23 Volume:66 Page:16168-16186
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Xufen¹²^ORCID,Li Dongxu³⁴^ORCID,Kottur Jithesh¹²,Kim Huen Suk¹²,Herring Laura E.⁵^ORCID,Yu Yao³⁴⁶⁷⁸,Xie Ling⁴,Hu Xiaoping¹²,Chen Xian⁴,Cai Ling³⁶⁷,Liu Jing¹²,Aggarwal Aneel K.²,Wang Gang Greg³⁴⁵⁶⁷,Jin Jian¹²^ORCID

Affiliation:

1. Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

2. Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States

4. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

5. Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States

6. Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina 27710, United States

7. Department of Pathology, Duke University School of Medicine, Durham, North Carolina 27710, United States

8. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, United States

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01521

Reference59 articles.

1. Moonlighting with WDR5: A Cellular Multitasker

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5. Structural Basis for the Specific Recognition of Methylated Histone H3 Lysine 4 by the WD-40 Protein WDR5

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