Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors

Published:2023-12-12 Issue:24 Volume:66 Page:16783-16806
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Teuscher Kevin B.^ORCID,Mills Jonathan J.^ORCID,Tian Jianhua¹,Han Changho^ORCID,Meyers Kenneth M.,Sai Jiqing,South Taylor M.,Crow Mackenzie M.,Van Meveren Mayme,Sensintaffar John L.,Zhao Bin,Amporndanai Kangsa^ORCID,Moore William J.²,Stott Gordon M.³,Tansey William P.,Lee Taekyu,Fesik Stephen W.⁴^ORCID

Affiliation:

1. Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232-0142, United States

2. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States

3. Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States

4. Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0142, United States

Funder

Vanderbilt University

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01529

Reference69 articles.

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3. Human Genome and Diseases:¶WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases

4. A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex

5. Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1*

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