Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography-Reference-Cited by-同舟云学术

Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography

Published:2023-12-29 Issue:1 Volume:67 Page:774-781
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Smith Christopher R.¹^ORCID,Chen Dan²,Christensen James G.¹,Coulombe René³,Féthière James³,Gunn Robin J.¹,Hollander Johan²,Jones Benjamin¹,Ketcham John M.¹^ORCID,Khare Shilpi¹,Kuehler Jon¹,Lawson J. David¹^ORCID,Marx Matthew A.¹^ORCID,Olson Peter¹,Pearson Kelly E.¹^ORCID,Ren Cynthia¹,Tsagris Denise²,Ulaganathan Thirumalaiselvi³,Van’t Veer Inge²,Wang Xiaolun¹,Ivetac Anthony¹

Affiliation:

1. Mirati Therapeutics, San Diego, California 92130, United States

2. ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands

3. Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02140

Reference42 articles.

1. SOS GEFs in health and disease

2. Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

3. Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

4. Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

5. Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development

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